189019-65-6Relevant academic research and scientific papers
Cyclic nitrones
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, (2008/06/13)
The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.
Cyclic nitrone free radical traps: Isolation, identification, and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects
Thomas, Craig E.,Bernardelli, Patrick,Bowen, S. Marc,Chaney, Stephen F.,Friedrich, Dirk,Janowick, David A.,Jones, Bryan K.,Keeley, Frederick J.,Kehne, John H.,Ketteler, Bert,Ohlweiler, David F.,Paquette, Leo A.,Robke, David J.,Fevig, Thomas L.
, p. 4997 - 5004 (2007/10/03)
A C-4 hydroxylated metabolite (2, 3,3-dimethyl-3,4-dihydroisoquinolin- 4-ol N-oxide) of the previously described cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroisoquinoline N-oxide, a cyclic analog of phenyl- tert-butylnitrone (PBN)) was isol
