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1890208-58-8 Usage

General Description

Compound 7P is a chemical compound that is primarily used as a pharmaceutical ingredient in the production of medications such as anticancer agents. It is a potent inhibitor of the enzyme topoisomerase I, which is responsible for unwinding and winding the DNA helix during DNA replication. This inhibition disrupts the replication and transcription process, leading to the arrest of cells in the S-phase of the cell cycle and ultimately resulting in apoptosis, or programmed cell death. Compound 7P has shown promising results in preclinical studies, demonstrating its potential as a valuable tool in the development of new cancer treatments. Its unique mechanism of action and high potency make it a significant chemical in the field of medicinal chemistry and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 1890208-58-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,9,0,2,0 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1890208-58:
188 % 10 = 8
So 1890208-58-8 is a valid CAS Registry Number.

1890208-58-8Downstream Products

1890208-58-8Relevant articles and documents

Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration

Ku, Jin-Mo,Park, Kyuhee,Lee, Jung Hun,Cho, Kyong Jin,Nam, Yeon-Ju,Jeong, Dae-Youn,Kim, Yu-Han,Kwon, Soonjung,Park, Ju-Young,Yang, Jungeun,Nam, Tae-Gyu,Yoon, Sung-Hwa,Ahn, Sangmee,Choi, Yongmun

, p. 4676 - 4687 (2016/06/13)

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

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