1890208-58-8 Usage
Description
Compound 7P is a pharmaceutical ingredient and a potent inhibitor of topoisomerase I enzyme, which plays a crucial role in DNA replication by unwinding and winding the DNA helix. Its inhibition of this enzyme disrupts the replication and transcription processes, leading to cell cycle arrest in the S-phase and ultimately inducing apoptosis. This unique mechanism of action and high potency make Compound 7P a significant chemical in medicinal chemistry and drug discovery, with promising results in preclinical studies for the development of new cancer treatments.
Uses
Used in Pharmaceutical Industry:
Compound 7P is used as an active pharmaceutical ingredient for the development of anticancer agents. Its ability to inhibit topoisomerase I enzyme and induce apoptosis makes it a valuable tool in the fight against cancer.
Used in Cancer Treatment:
Compound 7P is used as a chemotherapeutic agent for the treatment of various types of cancer. Its high potency and unique mechanism of action contribute to its potential as an effective cancer treatment, with the ability to disrupt DNA replication and transcription processes, leading to cell cycle arrest and apoptosis.
Used in Drug Discovery:
Compound 7P is used as a significant chemical in the field of drug discovery, particularly in the search for new cancer treatments. Its promising results in preclinical studies highlight its potential as a valuable tool in the development of innovative and effective medications.
Used in Medicinal Chemistry:
Compound 7P is used in medicinal chemistry for the study and development of new pharmaceutical compounds. Its unique properties and high potency make it an important chemical in understanding the mechanisms of action and potential applications of various drugs, particularly in the treatment of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1890208-58-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,9,0,2,0 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1890208-58:
(9*1)+(8*8)+(7*9)+(6*0)+(5*2)+(4*0)+(3*8)+(2*5)+(1*8)=188
188 % 10 = 8
So 1890208-58-8 is a valid CAS Registry Number.
1890208-58-8Relevant articles and documents
Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration
Ku, Jin-Mo,Park, Kyuhee,Lee, Jung Hun,Cho, Kyong Jin,Nam, Yeon-Ju,Jeong, Dae-Youn,Kim, Yu-Han,Kwon, Soonjung,Park, Ju-Young,Yang, Jungeun,Nam, Tae-Gyu,Yoon, Sung-Hwa,Ahn, Sangmee,Choi, Yongmun
, p. 4676 - 4687 (2016/06/13)
Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.
