18903-54-3Relevant academic research and scientific papers
Difluoromethane as a precursor to difluoromethyl borates
Geri, Jacob B.,Aguilera, Ellen Y.,Szymczak, Nathaniel K.
, p. 5119 - 5122 (2019)
Difluoromethane (CF2H2) is an ecologically-friendly refrigerant which holds promise as a source of CF2H-. However, the weak acidity (pKa = 35-41) and low stability of the conjugate base have prevented its utilization as a chemical feedstock. In this manuscript, we use a Lewis pair approach to deprotonate CF2H2 and capture CF2H- as R3B-CF2H- adducts. One reagent can be used as a base-free Suzuki reagent in palladium-mediated difluoromethylation, where CF2H- transfer is templated by precoordination to an azaborine derived R3B-CF2H- reagent..
DIFLUOROMETHYL AND DIFLUOROMETHYLENE TRANSFER REAGENTS
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Paragraph 0135-0136, (2020/01/22)
Disclosed herein are borazine, borate, and azaborinine compounds and compositions, methods of making said compounds and compositions, and methods of forming aromatic difluorocarbon compounds and difluorocarbon compounds.
