18826-95-4Relevant academic research and scientific papers
METHOD FOR PRODUCING ALCOHOL
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Paragraph 0104; 0106, (2022/02/05)
The present invention provides a method for selectively producing an alcohol by efficiently hydrogenating a lactone. The present invention is a method for producing an alcohol, the method including hydrogenating a substrate lactone represented by Formula (1), in the presence of a catalyst described below, to produce an alcohol that is represented by Formula (2). In the formulae, R represents a divalent hydrocarbon group which may have a hydroxyl group. The catalyst comprises: metal species including M1 and M2; and a support supporting the metal species, and wherein M1 is rhodium, platinum, ruthenium, iridium, or palladium; M2 is tin, vanadium, molybdenum, tungsten, or rhenium; and the support is hydroxyapatite, fluorapatite, hydrotalcite, or ZrO2.
1,3-BUTYLENE GLYCOL PRODUCT
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Paragraph 0060, (2021/03/19)
To provide a high-purity 1,3-butylene glycol product which is colorless and odorless and is less likely to be colored with a lapse of time.SOLUTION: In a gas chromatographic analysis under specific conditions, an area ratio of a peak of 1,3-butylene glycol is 99.5% or more, and an APHA after holding at 180°C for 3 hours in an air atmosphere is 40 or less. When the relative retention time of the peak of 1,3-butylene glycol is 1.0, an area ratio of a peak appearing in the relative retention time in the range of 2.3 to 2.4 is more than 0 ppm and 150 ppm or less. A component applicable to the peak which appears in the relative retention time in the range of 2.3 to 2.4 includes an acetal product of 1,3-butylene glycol and acetaldol.SELECTED DRAWING: Figure 1
METHOD FOR PRODUCING 1,3-BUTANEDIOL
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Paragraph 0046-0049, (2021/04/23)
PROBLEM TO BE SOLVED: To achieve high conversion rates and selectivity coefficients in producing 1,3-butanediol by performing the hydrogenation of acetaldol obtained by the condensation of acetaldehyde. SOLUTION: A method for producing 1,3-butanediol includes hydrogenating acetaldol with a hydrogen gas, using a hydrogenation catalyst. From a reaction solution after hydrogenation, a low-boiling component of a reaction by-product is separated and collected, and all or part of the low-boiling component is used to dilute acetaldol as raw material, after which hydrogenation is performed. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Chemoenzymatic Buta-1,3-diene Synthesis from Syngas Using Biological Decarboxylative Claisen Condensation and Zeolite-Based Dehydration
Balasubramaniam, Sivaraman,Badle, Sneh,Badgujar, Swati,Veetil, Vinod P.,Rangaswamy, Vidhya
, p. 705 - 711 (2020/12/01)
A method for producing buta-1,3-diene (1,3-BD) by an amalgamation of chemical and biological approaches with syngas as the carbon source is proposed. Syngas is converted to the central intermediate, acetyl-CoA, by microorganisms through a tetrahydrofolate metabolism pathway. Acetyl-CoA is subsequently converted to malonyl-CoA using a carbonyl donor in the presence of a carboxylase enzyme. A decarboxylative Claisen condensation of malonyl-CoA and acetaldehyde ensues in the presence of acyltransferases to form 3-hydroxybutyryl-CoA, which is subsequently reduced by aldehyde reductase to give butane-1,3-diol (1,3-BDO). An ensuing dehydration step converts 1,3-BDO to 1,3-BD in the presence of a chemical dehydrating reagent.
Method for preparing alcohol compound through hydrogenation of carbonyl-containing compound
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Paragraph 0050-0055, (2021/07/10)
The invention provides a method for preparing an alcohol compound through hydrogenation of a carbonyl-containing compound, the method comprises the following steps: firstly, contacting the carbonyl-containing compound with a nickel catalyst precursor to obtain a nickel-containing solution, then carrying out a contact reaction on the nickel-containing solution and hydrogen, converting the contained nickel into a nickel catalyst, and carrying out in-situ catalysis on the hydrogenation reaction of the carbonyl-containing compound, and obtaining the alcohol compound. According to the preparation method provided by the invention, the preparation of the nickel catalyst and the hydrogenation reaction of the carbonyl-containing compound are carried out in the same technological process for the first time, the prepared nickel catalyst is good in catalytic activity and long in service life, and the alcohol compound prepared by in-situ catalysis is high in yield and good in selectivity, so that the production cost of the alcohol compound can be remarkably reduced, the production efficiency is improved, and the method is particularly suitable for large-scale industrial production.
Hydrodeoxygenation of C4-C6 sugar alcohols to diols or mono-alcohols with the retention of the carbon chain over a silica-supported tungsten oxide-modified platinum catalyst
Betchaku, Mii,Cao, Ji,Liu, Lujie,Nakagawa, Yoshinao,Tamura, Masazumi,Tomishige, Keiichi,Yabushita, Mizuho
supporting information, p. 5665 - 5679 (2021/08/16)
The hydrodeoxygenation of erythritol, xylitol, and sorbitol was investigated over a Pt-WOx/SiO2 (4 wt% Pt, W/Pt = 0.25, molar ratio) catalyst. 1,4-Butanediol can be selectively produced with 51% yield (carbon based) by erythritol hydrodeoxygenation at 413 K, based on the selectivity over this catalyst toward the regioselective removal of the C-O bond in the -O-C-CH2OH structure. Because the catalyst is also active in the hydrodeoxygenation of other polyols to some extent but much less active in that of mono-alcohols, at higher temperature (453 K), mono-alcohols can be produced from sugar alcohols. A good total yield (59%) of pentanols can be obtained from xylitol, which is mainly converted to C2 + C3 products in the literature hydrogenolysis systems. It can be applied to the hydrodeoxygenation of other sugar alcohols to mono-alcohols with high yields as well, such as erythritol to butanols (74%) and sorbitol to hexanols (59%) with very small amounts of C-C bond cleavage products. The active site is suggested to be the Pt-WOx interfacial site, which is supported by the reaction and characterization results (TEM and XAFS). WOx/SiO2 selectively catalyzed the dehydration of xylitol to 1,4-anhydroxylitol, whereas Pt-WOx/SiO2 promoted the transformation of xylitol to pentanols with 1,3,5-pentanetriol as the main intermediate. Pre-calcination of the reused catalyst at 573 K is important to prevent coke formation and to improve the reusability.
Method for synthesizing 1, 3-dihydric alcohol by using olefin and methanol as raw materials
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Paragraph 0094-0120, (2021/07/28)
The invention discloses a method for preparing 1, 3-dihydric alcohol by taking olefin and methanol as raw materials through one-step reaction and a catalyst for the method. The method comprises the following steps: 1) adding a catalyst into a reactor, heating and reducing in a hydrogen-nitrogen mixed atmosphere, then cooling to 60-180 DEG C, and keeping the pressure in the reactor to be 0.5-8 MPa for reaction; 2) respectively introducing olefin and a methanol aqueous solution into the reactor for reaction, wherein the airspeed is 0.01-10h in terms of methanol; 3) enabling that the reaction product enters a product storage tank after condensation and gas-liquid separation; and 4) carrying out rectification separation on the reaction product obtained in the step 3) to obtain a 1, 3-dihydric alcohol product with the purity of more than 99%. The method provided by the invention has the advantages of low raw material cost, simple steps and continuous production.
Method for preparing 1, 3-butanediol through acetaldehyde condensation
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Paragraph 0041-0049; 0053; 0060-0061; 0065-0090, (2021/05/12)
The invention discloses a method for preparing 1, 3-butanediol through acetaldehyde condensation, which comprises the following steps: 1) adding 1, 3-butanediol and a solid acid catalyst into acetaldehyde condensation reaction liquid, and enabling 3-hydroxybutyraldehyde and condensation byproducts in the reaction liquid to completely react with the 1, 3-butanediol to generate an intermediate; and 2) rectifying to separate out acetaldehyde, and then hydrolyzing and hydrogenating the reaction liquid to generate the product 1, 3-butanediol from the intermediate generated in the reaction. The preparation method has the main advantages of high acetaldehyde recovery rate (greater than or equal to 95%), easiness in separation, low production cost, simplicity in operation and the like, and is suitable for industrial production.
Preparation method of 1,3-butanediol
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Paragraph 0077; 0078; 0079; 0080; 0081, (2020/03/05)
The invention provides a preparation method of 1,3-butanediol, which comprises the following steps: acetaldehyde condensation, hydrogenation and separation. In the hydrogenation step, the purity of the prepared 1,3-butanediol is greater than 99.5% by adopting methods of staged hydrogenation, addition of a modifier into a hydrogenation catalyst and the like, the content of 1,3-dioxane impurity canbe reduced to 0.01 wt% or below, and the product is odorless. The method has the advantages of simple process, low energy consumption, simple operation, high yield and selectivity of 1,3-butanediol, high purity of 1,3-butanediol and the like, and odorless 1,3-butanediol can be obtained.
Method for improving selectivity of aldol condensation reaction
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Paragraph 0024-0027; 0031-0036, (2020/09/16)
The invention provides a method for improving selectivity of aldol condensation reaction. The method comprises the following steps: introducing C1-C5 aldehyde participating in the reaction and an aqueous solution of an alkaline compound into a coiled tube type reactor in a parallel flow manner, forming a continuous phase under a turbulence condition by the aqueous solution of the alkaline compound, and dispersing the C1-C5 aldehyde in the continuous phase in a droplet form. The C1-C5 aldehyde is selected from one or two of formaldehyde, acetaldehyde, propionaldehyde, n-butyraldehyde, isobutyraldehyde, n-valeraldehyde and isovaleraldehyde; the alkaline compound is selected from at least one of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate,ammonia water, trimethylamine, triethylamine and diisopropylamine. The invention also provides preparation of 1, 3-butanediol by condensation of acetaldehyde and an inorganic alkali compound and preparation of hydroxypivalaldehyde by condensation of formaldehyde, isobutyraldehyde and a trimethylamine aqueous solution. With application of the coiled tube type reactor, the reaction temperature, thematerial ratio and the retention time can be accurately controlled, side reactions are effectively reduced, and the reaction efficiency, the reaction stability and the product selectivity are improvedby adopting the reaction process.
