189064-48-0

Usage

Chemical Properties

Brown Oil

Uses

Intermediate for the synthesis of Carebastine

InChI:InChI=1/C33H39NO4/c1-33(2,32(36)37-3)28-18-16-25(17-19-28)30(35)15-10-22-34-23-20-29(21-24-34)38-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3

Upstream product

• 158584-63-5 C₂₀H₂₉NO₄ 
• 90-99-3 diphenylchloromethane 
• 97928-45-5 4-diphenylmethoxy-1-[3-(4-bromobenzoyl)propyl]-piperidine 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 58258-01-8 4-diphenylmethoxypiperidine 
• 154477-54-0 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 

Relevant academic research and scientific papers

Process for production of carebastine

Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.