189071-56-5

Upstream product

• 5470-84-8 4-benzyloxybutanal 
• 56-40-6 glycine 

Downstream Products

• 184005-99-0 (S)-6-Benzyloxy-2-tert-butoxycarbonylamino-3-hydroxy-hexanoic acid 
• 270086-13-0 (2S,3R)-2-amino-6-(benzyloxy)-3-hydroxyhexanoic acid 
• 176703-34-7 methyl (2S,3S)-2-acetamido-6-benzyloxy-3-hydroxyhexanoate 
• 157183-67-0 (2S,3S)-(E)-2-amino-3-hydroxy-2-hydroxymethyl-14-oxoicos-6-enoic acid 
• 176703-36-9 methyl (4S,5S)-4-acetoxymethyl-5-(2-formylethyl)-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 176703-31-4 methyl (4S,5S)-5-(3-benzyloxypropyl)-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 176703-32-5 methyl (2S,3R)-2-benzamido-6-benzyloxy-3-hydroxyhexanoate 
• 176703-37-0 methyl (4S,5S)-4-acetoxymethyl-5-[(3E)-11,11-ethylenedioxyheptadec-3-enyl]-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 176703-33-6 methyl (4S,5S)-4-acetoxymethyl-5-(3-benzyloxypropyl)-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 270086-15-2 methyl (2S,3R)-2-acetamido-6-benzyloxy-3-hydroxyhexanoate 
• 270086-11-8 methyl (4S,5S)-4-acetoxymethyl-5-(3-hydroxypropyl)-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 1055036-36-6 (4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 270086-12-9 methyl (4S,5S)-4-acetoxymethyl-5-[(3Z)-11,11-ethylenedioxyheptadec-3-enyl]-2-phenyl-Δ²-oxazoline-4-carboxylate 
• 184005-56-9 (S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide 

Relevant academic research and scientific papers

L-threonine aldolase in organic synthesis: Preparation of novel β-hydroxy-α-amino acids

The L-threonine aldolase from Candida humicola was used in the synthesis of multifunctional β-hydroxy-α-amino acids. Of many aldehydes with different substituents tested as substrates for reaction with glycine, benzyloxy- and alkoxy-aldehydes are found to be good substrates, providing a new synthetic route to α-amino-β,ω-dihydroxy and α,ω-diamino-β-hydroxy acids. The enzymatic reactions are not stereospecific regarding the new stereocenter formed at the β-carbon, though they all give L-α-amino acids.