189082-99-3

Basic information

• Product Name: Silane, [2-bromo-4,5-bis(phenylmethoxy)phenoxy](1,1-dimethylethyl)dimethyl-
• CAS NO: 189082-99-3
• Molecular Formula: C26H31BrO3Si
• Molecular Weight: 499.52
• Mol File: 189082-99-3.mol

Chemical Properties

• CAS DataBase Reference: Silane, [2-bromo-4,5-bis(phenylmethoxy)phenoxy](1,1-dimethylethyl)dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [2-bromo-4,5-bis(phenylmethoxy)phenoxy](1,1-dimethylethyl)dimethyl-(189082-99-3)
• EPA Substance Registry System: Silane, [2-bromo-4,5-bis(phenylmethoxy)phenoxy](1,1-dimethylethyl)dimethyl-(189082-99-3)

Safety Data

• Hazardous Substances Data: 189082-99-3(Hazardous Substances Data)

Upstream product

• 120951-85-1 1,2-di-O-benzyl-4-O-tert-butyldimethylsilylbenzenetriol 
• 27688-86-4 3,4-dibenzyloxyphenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 189082-97-1 3,4-bis(benzyloxy)phenyl formate 

Downstream Products

• 851279-15-7 3,4-di-benzyloxy-6-(7'-drimen-11'-ylidene)-2,4-cyclohexadienone 
• 206862-16-0 4,5-Bis-benzyloxy-2-(2,6,6-trimethyl-cyclohex-1-enylmethyl)-phenol 
• 257288-40-7 acetate of 2-(8α,9α-epoxy-driman-11-yl)-4,5-dibenzyloxyphenyl 
• 257288-41-8 acetate of 2-(8β,9β-epoxy-driman-11-yl)-4,5-dibenzyloxyphenyl 
• 257288-42-9 9α-hydroxy-di-O-benzylpuupehenol 
• 257288-39-4 acetate of 2-(8-drimen-11-yl)-4,5-dibenzyloxyphenyl 
• 257288-33-8 8-epi-19,20-di-O-benzyl-puupehenol 
• 257288-32-7 2-(8-drimen-11-yl)-4,5-dibenzyloxyphenol 
• 257288-37-2 2-Benzyloxy-5-((4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone 
• 257288-31-6 11-(2-tert-butyldimethylsilyloxy-4,5-di-benzyloxyphenyl)-8-drimene 
• 206862-14-8 [4,5-Bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-(2,6,6-trimethyl-cyclohex-1-enyl)-methanol 
• 247577-70-4 Acetic acid (R)-[4,5-bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyl-decahydro-naphthalen-1-yl)-methyl ester 

Relevant articles and documents

Synthesis and antitumor activity of puupehedione and related compounds

The first enantiospecific synthesis of bioactive marine puupehedione (2) and related compounds from (-)-sclareol (11) is reported. The antitumor activity of these compounds was assayed and compared with that of the natural products.

Enantiospecific synthesis of (+)-puupehenone from (-)-sclareol and protocatechualdehyde

The first enantiospecific synthesis of the antitumor and cholesteryl ester transfer protein (CETP) inhibitor (+)-puupehenone (19) from (-)-sclareol (10) and protocatechualdehyde (4) is described. The key steps of the reaction sequence are the organoselenium-induced cyclization of the mixture of regioisomers 15a-b to give 16 and 17, with complete diastereoselectivity, and the simultaneous removal of benzyl and phenylselenyl groups of 16 and 17 by treating with Raney Ni.