189090-95-7

Upstream product

• 100-39-0 benzyl bromide 
• 87050-89-3 2,4-bis(trimethylsilyl)furan 
• 126386-46-7 3,4-Bis(trimethylsilyl)furan 
• 14630-40-1 Bis(trimethylsilyl)ethyne 

Downstream Products

• 189091-02-9 (2-Benzyl-5-iodo-furan-3-yl)-trimethyl-silane 
• 95264-71-4 (2-Benzyl-furan-3-yl)-trimethyl-silane 
• 189091-20-1 (2-Benzyl-5-p-tolyl-furan-3-yl)-trimethyl-silane 

Relevant academic research and scientific papers

Regiospecific synthesis of polysubstituted furans from silylated furans: Expedient syntheses of rosefuran

By utilizing a sequence of regiospecific lithiation-alkylation, ipso-iodination, boroxine formation, Sonogashira cross-coupling, nickel-catalyzed cross-coupling and Suzuki cross-coupling reactions, several methods have been developed for the syntheses of 2,3-disubstituted furans; 2,4-disubstituted furans, 2,3,4-trisubstituted furans and 2,3,5-trisubstituted furans; Our approach uses as the key theme trimethylsilyl groups as both blacking groups as well as ipso-directing groups. The advantage of this program is aptly illustrated by two expedient syntheses of rosefuran (9c).