1891-73-2Relevant academic research and scientific papers
The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B
Evans, Gary B.,Furneaux, Richard H.,Gainsford, Graeme J.,Murphy, Michael P.
, p. 1663 - 1675 (2007/10/03)
Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.
