297179-13-6

Basic information

• Product Name: 2,9-Phenanthrenediol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS,9R)-
• Synonyms: 2,9-Phenanthrenediol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS,9R)-
• CAS NO: 297179-13-6
• Molecular Formula: C20H30 O2
• Molecular Weight: 0
• Mol File: 297179-13-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,9-Phenanthrenediol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS,9R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,9-Phenanthrenediol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS,9R)-(297179-13-6)
• EPA Substance Registry System: 2,9-Phenanthrenediol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS,9R)-(297179-13-6)

Safety Data

• Hazardous Substances Data: 297179-13-6(Hazardous Substances Data)

Usage

Derived from

Phenanthrene

Hydroxyl groups

Located at the 2nd and 9th positions

Structure

Bicyclic with a saturated carbon ring

Substituents

Methyl group and isopropyl group

Stereochemistry

(4bS,8aS,9R)

Applications

Potential uses in research and industry (dependent on further investigation and characterization)

Upstream product

• 1891-74-3 13-acetoxy-6α,7α-epoxytotara-8,11,13-triene 
• 1891-73-2 13-acetoxytotara-7,8,11,13-tetarene 
• 1891-75-4 13-acetoxytotara-8,11,13-trien-6α-ol 
• 54146-06-4 7α-acetoxy-13-methoxytotara-8,11,13-triene 
• 15423-38-8 13-methoxytotara-6,8,11,13-tetraene 
• 297179-15-8 6-oxototara-8,11,13-trien-13-ol 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B

Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.