189116-10-7Relevant academic research and scientific papers
Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives
Chakrapani,Ramesh,Pourna Chander Rao,Ramachandran,Madhukar Reddy,Kalyan Chakravarthy,Sridhar, Gattu
, p. 1020 - 1024 (2018)
A series of 1,2,4-oxadiazole linked imidazothiadiazole derivatives 11a–11j have been synthesized. All derivatives were evaluated for anticancer activity against three human cancer cell lines (A375, MCF-7, and ACHN) and demonstrated activity comparable with that of doxorubicin. Three compounds 11b, 11c, and 11j exhibited higher anticancer activity than the positive control. The range of IC50 for the compounds 11b, 11c, and 11j is determined to be from 0.11 to 2.98 μM.
Synthesis of imidazo[2,1-b][1,3,4]thiadiazole-chalcones as apoptosis inducing anticancer agents
Kamal, Ahmed,Reddy, Vangala Santhosh,Santosh, Karnewar,Bharath Kumar,Shaik, Anver Basha,Mahesh, Rasala,Chourasiya, Sumit. S.,Sayeed, Ibrahim Bin,Kotamraju, Srigiridhar
, p. 1718 - 1723 (2014)
A series of new imidazo[2,1-b][1,3,4]thiadiazole-chalcones were synthesized by Claisen-Schmidt condensation and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds showed moderate to appreciable antiproliferativ
