189129-08-6

Basic information

• Product Name: C₃₀H₂₆N₄O₈
• Synonyms: C₃₀H₂₆N₄O₈
• CAS NO: 189129-08-6
• Molecular Weight: 570.558
• Mol File: 189129-08-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₆N₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₆N₄O₈(189129-08-6)
• EPA Substance Registry System: C₃₀H₂₆N₄O₈(189129-08-6)

Safety Data

• Hazardous Substances Data: 189129-08-6(Hazardous Substances Data)

Upstream product

• 5991-01-5 2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride 
• 80646-61-3 (4-Methyl-6-trimethylsilanyloxy-[1,3,5]triazin-2-yl)-trimethylsilanyl-amine 

Downstream Products

• 16352-06-0 6-methyl-5-azacytosine 
• 62374-52-1 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl 2,3,5-tri-O-benzoyl-β-D-ribofuranoside 
• 67525-66-0 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 189129-04-2 C₃₀H₂₆N₄O₈ 
• 105330-91-4 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 1824-96-0 methyl ribofuranoside 

Relevant articles and documents

6-Methyl-5-azacytidine - Synthesis, conformational properties and biological activity. A comparison of molecular conformation with 5- azacytidine

The title compound was prepared by the isocyanate procedure and the trimethylsilyl method. The measurement of 1H NMR spectrum of 6-methyl-5- azacytidine (1) revealed a preference of γ(t) (46%) rotamer around C(5')- C(4') bond, a predominance of N conformation of the ribose ring (K(eq) 0.33) and a preference of syn conformation around the C-N glycosyl bond. An analogous measurement of 5-azacytidine has shown a preference of γ+ (60%) rotamer around the C(5')-C(4') bond, a predominance of N conformation of the fibose ring (K(eq) 0.41) and a preference of anti conformation around the C- N glycosyl bond 6-Methyl-5-azacytidine (1) inhibits the growth of bacteria E coli to the extent of 85% at 4000 μM concentration and the growth of LoVo/L, a human colon carcinoma cell line, to the extent of 30% at 100 μM concentration but did not inhibit L1210 cells at ≤ 100 μM concentration 6- Methyl-5-azacytidine (1) exhibited no in vitro antiviral activity at ≤ 1 μM concentration.