105330-91-4

Basic information

• Product Name: 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine
• Synonyms: 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine
• CAS NO: 105330-91-4
• Molecular Weight: 570.558
• Mol File: 105330-91-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine(105330-91-4)
• EPA Substance Registry System: 2',3',5'-tri-O-benzoyl-6-methyl-5-azacytidine(105330-91-4)

Safety Data

• Hazardous Substances Data: 105330-91-4(Hazardous Substances Data)

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 80646-61-3 (4-Methyl-6-trimethylsilanyloxy-[1,3,5]triazin-2-yl)-trimethylsilanyl-amine 
• 21823-89-2 2,3,5-tri-O-benzoyl-β-D-ribosyl isocyanate 
• 189129-04-2 C₃₀H₂₆N₄O₈ 
• 189131-47-3 N-(acetylamidino)-N'-(2,3,5-tri-O-benzoyl-β-D-ribosyl)urea 
• 189129-08-6 C₃₀H₂₆N₄O₈ 
• 5991-01-5 2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride 

Downstream Products

• 16352-06-0 6-methyl-5-azacytosine 
• 62374-52-1 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl 2,3,5-tri-O-benzoyl-β-D-ribofuranoside 
• 67525-66-0 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 189129-04-2 C₃₀H₂₆N₄O₈ 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 

Relevant articles and documents

Synthesis and antiproliferative activities of 5-azacytidine analogues in human leukemia cells

Twenty-six 5-azacytidine analogues have been synthesized, including 4-amino-6-alkyl-1-pyranosyl/ribofuranosyl-1,3,5-triazin-2(1H)-ones 1a-j, 6-amino-4-alkyl/aryl-1-pyranosyl/ribofuranosyl-1,3,5-triazin-2(1H)-ones 2a-f and 4-amino-6-alkyl-1,3,5-triazin-2-yl-1-thio-pyranosides/ribofuranosides 3a-j. The antiproliferative activities of these synthetic analogues were investigated in human leukemia HL-60 cells. Ribofuranosyl S-nucleoside 3a, a bioisostere of 5-azacytidine, had a similar antiproliferative ability as that of the latter. Introduction of a methyl at the 6 position of 5-azacytidine and/or replacement of the ribofuranosyl moiety with pyranosyl sugars or disaccharides significantly decreased the antiproliferative activities of the 5-azacytidine derivatives. Several compounds with the replacement of pyranosyl sugars enhanced all-trans retinoic acid-induced differentiation ability in human leukemia HL-60 cells.