189129-90-6Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents
Kumar, Versha Vinay,Singh, Sudhir K.,Sharma,Bhaduri,Gupta, Suman,Zaidi, Alima,Tiwari, Suman,Katiyar
, p. 675 - 680 (2007/10/03)
Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.
