18915-36-1

Usage

General Description

1,2,4-Triazin-3-amine,6-methyl-(9CI) is a chemical compound with the molecular formula C5H7N5. It is a derivative of triazine, a six-membered heterocyclic ring containing three nitrogen atoms. 1,2,4-Triazin-3-amine,6-methyl-(9CI) is also known as 6-methyl-1,2,4-triazin-3-amine and is used mainly as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has the potential to exhibit biological activity and may be used in the development of new drugs. Additionally, it may have application as a component in the production of herbicides and fungicides. Further research and testing may reveal additional uses and potential applications for 1,2,4-Triazin-3-amine,6-methyl-(9CI).

Upstream product

• 2582-30-1 aminoguanidine bicarbonate 
• 78-98-8 2-oxopropanal 
• 823-96-1 Trimethylboroxine 
• 69249-22-5 3-Amino-6-bromo-1,2,4-triazine 
• 2200-97-7 aminoguanidine hydrogencarbonate 

Downstream Products

• 1384878-10-7 4-hydroxy-3-(4-isopropylbenzoyl)-1-(6-methyl-1,2,4-triazin-3-yl)-2-[4-(trifluoromethoxy)phenyl]-2H-pyrrol-5-one 

Relevant academic research and scientific papers

Imidazotriazine and imidazodiazine compounds

The present invention provides thiazole compounds of Formula I wherein X, Y, Z, X1, X2, X3, X4, X5, R1, R2, R4, R5, R6, R7, and W, are

Strain-Promoted Reaction of 1,2,4-Triazines with Bicyclononynes

Strain-promoted inverse electron-demand Diels-Alder cycloaddition (SPIEDAC) reactions between 1,2,4,5-tetrazines and strained dienophiles, such as bicyclononynes, are among the fastest bioorthogonal reactions. However, the synthesis of 1,2,4,5-tetrazines is complex and can involve volatile reagents. 1,2,4-Triazines also undergo cycloaddition reactions with acyclic and unstrained dienophiles at elevated temperatures, but their reaction with strained alkynes has not been described. We postulated that 1,2,4-triazines would react with strained alkynes at low temperatures and therefore provide an alternative to the tetrazine cycloaddition reaction for use in in vitro or in vivo labelling experiments. We describe the synthesis of a 1,2,4-triazin-3-ylalanine derivative fully compatible with the fluorenylmethyloxycarbonyl (Fmoc) strategy for peptide synthesis and demonstrate its reaction with strained bicyclononynes at 37°C with rates comparable to the reaction of azides with the same substrates. The synthetic route to triazinylalanine is readily adaptable to late-stage functionalization of other probe molecules, and the 1,2,4-triazine-SPIEDAC therefore has potential as an alternative to tetrazine cycloaddition for applications in cellular and biochemical studies.

1-(6-MEMBERED AZO-HETEROCYCLIC)-2,5-DIHYDRO-1H-PYRROL-2-ONE DERIVATIVES AS ANTI-HEPATITIS C VIRUS, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns 1-(6-memberedazo-heterocyclic)-2,5-dihydro–1H–pyrrol–2-one compoundsof the following formula (I) or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C virus.

Detection of α-Dicarbonyl compounds in Maillard reaction systems and in vivo

α-Dicarbonyl compounds are of major interest in food chemistry and biochemistry as important precursors of, for example, protein modifications and flavor. Due to their high reactivity most of the published structures were identified and quantitated as stable derivatives after reaction with trapping reagents. However, the present study showed for the first time that the trapping reagents are of dramatic impact on the final qualitative and quantitative α-dicarbonyl spectrum. As important representatives, aminoguanidine and o-phenylenediamine were used to compare trapping characteristics and to monitor the dicarbonyl structures arising from the degradation of an Amadori compound. Dicarbonyl structures with a reductone moiety could not be or were only insufficiently detected by slow-reacting reagents such as aminoguanidine. On the other hand, fast-reacting chemicals such as o-phenylenediamine imposed high oxidative stress on the investigated system and led to enhanced or false positive formation of dicarbonyl compounds generated by oxidative pathways.