189155-13-3Relevant academic research and scientific papers
The role of hydrophobic versus hydrophilic base character in the anti- HIV activity of purine-containing polyribonucleotides
Tutonda, Mayoka G.,Fain, Heidi D.,Buckheit Jr., Robert W.,Broom, Arthur D.
, p. 173 - 182 (1997)
In contrast to the highly amphiphilic poly(1-methyl-6-thioinosinic acid), a potent anti-HIV agent, poly(1-amino-6-thioinosinic acid) (PATI) lacks the unique melting behavior characteristic of the amphiphilic polymers and is completely devoid of anti-HIV activity. This is consistent with the hypothesis that amphiphilic character and the ability to form an ordered secondary structure in solution are prerequisites for potent anti-HIV activity of single-stranded polynucleotides.
