The role of hydrophobic versus hydrophilic base character in the anti- HIV activity of purine-containing polyribonucleotides

Article abstract of DOI:10.1080/07328319708002531

In contrast to the highly amphiphilic poly(1-methyl-6-thioinosinic acid), a potent anti-HIV agent, poly(1-amino-6-thioinosinic acid) (PATI) lacks the unique melting behavior characteristic of the amphiphilic polymers and is completely devoid of anti-HIV activity. This is consistent with the hypothesis that amphiphilic character and the ability to form an ordered secondary structure in solution are prerequisites for potent anti-HIV activity of single-stranded polynucleotides.

Full text of DOI:10.1080/07328319708002531

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
The Role of Hydrophobic Versus Hydrophilic
Base Character in the Anti-HIV Activity of Purine-
Containing Polyribonucleotides
Mayoka G. Tutonda , Heidi D. Fain , Robert W. Buckheit Jr. & Arthur D. Broom
To cite this article: Mayoka G. Tutonda , Heidi D. Fain , Robert W. Buckheit Jr. & Arthur D.
Broom (1997) The Role of Hydrophobic Versus Hydrophilic Base Character in the Anti-HIV
Activity of Purine-Containing Polyribonucleotides, Nucleosides and Nucleotides, 16:1-2,
173-182, DOI: 10.1080/07328319708002531
To link to this article: http://dx.doi.org/10.1080/07328319708002531
Published online: 20 Aug 2006.
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Date: 12 June 2016, At: 19:15