189159-93-1

Basic information

• Product Name: 1,4-anhydro-3-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol
• CAS NO: 189159-93-1
• Molecular Weight: 512.987
• Mol File: 189159-93-1.mol

Chemical Properties

• CAS DataBase Reference: 1,4-anhydro-3-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-anhydro-3-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol(189159-93-1)
• EPA Substance Registry System: 1,4-anhydro-3-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol(189159-93-1)

Safety Data

• Hazardous Substances Data: 189159-93-1(Hazardous Substances Data)

Upstream product

• 491-19-0 1,4-anhydro-D-ribitol 
• 189159-91-9 1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol 
• 189159-88-4 1,4-anhydro-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol 
• 189159-85-1 (3S,3aR,9aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene 
• 160308-05-4 3,5-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-1-deoxy-D-ribofuranose 

Relevant articles and documents

Introduction of a universal solid support for oligonucleotide synthesis

Protection of 1,4-anhydro-D-ribitol with the bidentate reagent 1,3- dichloro-1,1,3,3-tetraisopropyldisiloxane, followed by 4,4'- dimethoxytritylation, selective cleavage of the silyl group at the secondary oxygen, chloroacetylation, and desilylation at the 5-position, afforded 1,4- anhydro-3-O-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol. Derivatisation of the free hydroxyl group with LCAA-CPG gave a novel universal solid support for use in oligonucleotide synthesis and phosphoramidite-based combinatorial chemistry. This solid support was used for synthesis of a number of oligonucleotides, for which the purity and identity with oligonucleotides synthesised on commercial supports was demonstrated.