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189159-91-9

1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 189159-91-9 Structure

  • Basic information

    1. Product Name: 1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol
    2. Synonyms:
    3. CAS NO:189159-91-9
    4. Molecular Formula:
    5. Molecular Weight: 773.511
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 189159-91-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol(189159-91-9)
    11. EPA Substance Registry System: 1,4-anhydro-3-chloroacetyl-5-O-[diisopropyl(hydroxy)silyloxy(diisopropyl)silyl]-2-O-(4,4'-dimethoxytrityl)-D-ribitol(189159-91-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 189159-91-9(Hazardous Substances Data)

189159-91-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 189159-91-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,1,5 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 189159-91:
(8*1)+(7*8)+(6*9)+(5*1)+(4*5)+(3*9)+(2*9)+(1*1)=189
189 % 10 = 9
So 189159-91-9 is a valid CAS Registry Number.

189159-91-9Relevant articles and documents

Introduction of a universal solid support for oligonucleotide synthesis

Scheuer-Larsen, Claus,Rosenbohm, Christoph,Jorgensen, Thomas J. D.,Wengel, Jesper

, p. 67 - 80 (2007/10/03)

Protection of 1,4-anhydro-D-ribitol with the bidentate reagent 1,3- dichloro-1,1,3,3-tetraisopropyldisiloxane, followed by 4,4'- dimethoxytritylation, selective cleavage of the silyl group at the secondary oxygen, chloroacetylation, and desilylation at the 5-position, afforded 1,4- anhydro-3-O-chloroacetyl-2-O-(4,4'-dimethoxytrityl)-D-ribitol. Derivatisation of the free hydroxyl group with LCAA-CPG gave a novel universal solid support for use in oligonucleotide synthesis and phosphoramidite-based combinatorial chemistry. This solid support was used for synthesis of a number of oligonucleotides, for which the purity and identity with oligonucleotides synthesised on commercial supports was demonstrated.

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