18916-44-4Relevant academic research and scientific papers
C2-Selective C-H methylation of heterocyclic N-oxides with sulfonium ylides
An, Won,Choi, Su Bin,Kim, Namhoon,Kwon, Na Yeon,Ghosh, Prithwish,Han, Sang Hoon,Mishra, Neeraj Kumar,Han, Sangil,Hong, Sungwoo,Kim, In Su
supporting information, p. 9004 - 9009 (2020/11/30)
A redox-neutral C2-selective methylation of heterocyclic N-oxides with sulfonium ylides is described herein. This report presents unprecedented findings for the utility of sulfonium ylides as the methylation source of N-heterocycles beyond the Corey-Chaykovsky reaction. Intriguingly, pyrrolidine plays a significant role in minimizing the reductive C2-methylation process. This method is characterized by its mild conditions, simplicity, and excellent site selectivity. The applicability of the developed protocol is showcased by the late-stage methylation and sequential transformations of complex drug molecules.
PARTIAL REDUCTION OF QUINOXALINE 1,4-DIOXIDE DERIVATIVES WITH L-ASCORBIC ACID
Novacek, Libor,Nechvatal, Miloslav
, p. 1302 - 1306 (2007/10/02)
Partial reduction of quinoxaline 1,4-dioxide derivatives with L-ascorbic acid has been elaborated.Quinoxaline 1,4-dioxide, 2,3-dimethylquinoxaline 1,4-dioxide, 2-methylquinoxaline 1,4-dioxide and 2-(N-(2-hydroxyethyl)carbamoyl)-3-methylquinoxaline 1,4-dioxide afforded monoxides.In the monomethyl derivatives the more distant N-O bond is reduced.In addition to the monoxide, quinoxaline 1,4-dioxide afforded small amount of quinoxaline.Structures of all the compounds have been confirmed by 1H and 13C NMR spectroscopy.
