189160-72-3

Basic information

• Product Name: N-tert-Butoxycarbonyl-N-[2-(N³-benzoylthymin-1-yl)ethyl]glycine methyl ester
• CAS NO: 189160-72-3
• Molecular Weight: 445.472
• Mol File: 189160-72-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-Butoxycarbonyl-N-[2-(N³-benzoylthymin-1-yl)ethyl]glycine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butoxycarbonyl-N-[2-(N³-benzoylthymin-1-yl)ethyl]glycine methyl ester(189160-72-3)
• EPA Substance Registry System: N-tert-Butoxycarbonyl-N-[2-(N³-benzoylthymin-1-yl)ethyl]glycine methyl ester(189160-72-3)

Safety Data

• Hazardous Substances Data: 189160-72-3(Hazardous Substances Data)

Upstream product

• 4330-20-5 N-3-benzoylthymine 
• 189160-68-7 N-tert-Butoxycarbonyl-N-(2-hydroxyethyl)glycine methyl ester 
• 189160-67-6 [tert-butoxycarbonyl(2-hydroxyethyl)amino]acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Amino acids bearing nucleobases for the synthesis of novel peptide nucleic acids

All of the four nucleobases found in DNA have been incorporated in their protected form into the 4-position of N-tert-butoxycarbonyl-L-proline methyl ester with cis-stereochemistry. An efficient route for the synthesis of N-tert-butoxycarbonyl-trans-4-hydroxy-D-proline methyl ester has been developed from which the enantiomers may be synthesized. In addition an efficient synthesis of N-tert-butoxycarbonyl-N-(2-hydroxyethyl)glycine methyl ester has been achieved and its hydroxy group replaced with protected nucleobases using the Mitsunobu reaction.