189239-18-7Relevant academic research and scientific papers
Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors
Kolasa, Teodozyj,Bhatia, Pramila,Brooks, Clint D. W.,Hulkower, Keren I.,Bouska, Jennifer B.,Harris, Richard R.,Bell, Randy L.
, p. 507 - 514 (2007/10/03)
A series of substituted indolylalkoxyiminoalkylcarboxylates were found to be potent leukotriene biosynthesis inhibitors. The structure-activity relationships were investigated. Representative potent inhibitors identified were the quinolyl 3a (A-86885) and pyridyl 3b (A-86886) congeners with in vitro IC50s of 21 and 9 nM and in vivo leukotriene inhibition in the rat with oral ED50s of 0.9 and 1.7 mg/kg, respectively.
