18924-66-8Relevant academic research and scientific papers
Alkynyl quaternary ammonium salt multifunctional surfactants and preparation method thereof
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Paragraph 0064-0069, (2017/05/02)
The invention discloses a series of alkynyl quaternary ammonium salt multifunctional surfactants and a preparation method thereof. A structural formula of quaternary ammonium salt is shown in the description, wherein R represents a C4-C22 linear, branched or cycloalkyl, aryl or alkenyl group. The preparation method comprises the following steps: (1) carrying out alkylation on ethanol amine under alkaline and acetonitrile reflux conditions by virtue of bromo-hydrocarbon; and (2) carrying out further alkylation on tertiary amine under an ethanol reflux condition by virtue of propargyl bromide, so as to obtain alkynyl quaternary ammonium salt, namely reddish brown semitransparent viscous liquid or solid. The alkynyl quaternary ammonium salt multifunctional surfactants have very high surface activity, good corrosion resistance and excellent viscoelasticity, the preparation method is simple and feasible, the raw material cost is low, the operation is easy, the yield is high, and the surfactants are environmentally friendly.
Synthesis and antileishmanial activity of lipidic amino alcohols
Coimbra, Elaine S.,De Almeida, Mauro V.,Junior, Celso O. R.,Taveira, Aline F.,Da Costa, Cristiane F.,De Almeida, Ana C.,Reis, Elaine F. C.,Da Silva, Adilson D.
scheme or table, p. 233 - 235 (2010/12/20)
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 μm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines
Boukli, Latifa,Touaibia, Mohamed,Meddad-Belhabich, Nadia,Djimde, Atime,Park, Chang-Ha,Kim, Jung-Joo,Yoon, Joo-Hyoung,Lamouri, Aazdine,Heymans, Francoise
, p. 1242 - 1253 (2008/09/17)
Among the different PLA2s identified to date, the group IIA secretory PLA2 (sPLA2 GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 μM). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg).
Phosphorous amine lubricant additives
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, (2008/06/13)
Lubricant additives are produced by reacting an alkoxylated amine with phosphorous acid. The additives preferably also contain a boron moiety which is reacted with the phosphorous acid and amine, preferably in a one step reaction. More preferably, a mono-functional alcohol or a long-chain aliphatic carboxylic acid is added to this mixture. The additives are particularly useful in metal working oils and particularly as extreme pressure additives to replace the currently used chlorinated paraffin additives.
