189247-73-2Relevant academic research and scientific papers
Synthesis, Mechanism Elucidation and Biological Insights of Tellurium(IV)-Containing Heterocycles
Souza, Jo?o Pedro A.,Menezes, Leociley R. A.,Garcia, Francielle P.,Scariot, Débora B.,Bandeira, Pamela T.,Bespalhok, Mateus B.,Giese, Siddhartha O. K.,Hughes, David L.,Nakamura, Celso V.,Barison, Andersson,Oliveira, Alfredo R. M.,Campos, Renan B.,Piovan, Leandro
, p. 14427 - 14437 (2021)
Inspired by the synthetic and biological potential of organotellurium substances, a series of five- and six-membered ring organotelluranes containing a Te?O bond were synthesized and characterized. Theoretical calculations elucidated the mechanism for the oxidation-cyclization processes involved in the formation of the heterocycles, consistent with chlorine transfer to hydroxy telluride, followed by a cyclization step with simultaneous formation of the new Te?O bond and deprotonation of the OH group. Moreover, theoretical calculations also indicated anti-diastereoisomers to be major products for two chirality center–containing compounds. Antileishmanial assays against Leishmania amazonensis promastigotes disclosed 1,2λ4-oxatellurane LQ50 (IC50=4.1±1.0; SI=12), 1,2λ4-oxatellurolane LQ04 (IC50=7.0±1.3; SI=7) and 1,2λ4-benzoxatellurole LQ56 (IC50=5.7±0.3; SI=6) as more powerful and more selective compounds than the reference, being up to four times more active. A stability study supported by 125Te NMR analyses showed that these heterocycles do not suffer structural modifications in aqueous-organic media or at temperatures up to 65 °C.
Reactivity of chlorooxachalcogenuranes: Oxidation of sulfides to sulfoxides using chlorooxaselenuranes
Zhang, Jian,Koizumi, Toru
, p. 979 - 987 (2000)
The transformation of chloro between chlorooxachalcogenuranes 3 and chalcogenides 4 is described. The oxidative ability of chlorooxachalcogenuranes has been compared. Selenuranes 3a, b have been found to be good reagents for selective oxidation of sulfide
Synthesis of cyclic halooxatelluranes via dehalogenation of α-halo carbonyl compounds with tellurides containing hydroxy group on side chain
Zhang, Jian,Saito, Shinichi,Takahashi, Tamiko,Koizumi, Toru
, p. 575 - 584 (2007/10/03)
The synthesis of cyclic halooxatelluranes (3a, 4a-d, 5a) has been achieved via dehalogenation of α-halo carbonyl compounds (2A-F) with tellurides(1a-d) containing hydroxy group on the side chain. Halophilicity of the tellurides was compared with that of selenides and a plausible reaction mechanism is discussed.
