189291-08-5

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 67-56-1 methanol 
• 72-19-5 L-threonine 

Downstream Products

• 1268832-94-5 N-((2R,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-hydroxybutan-2-yl)-2,4,6-trimethylbenzenesulfonamide 
• 1268832-95-6 (R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine 
• 1268832-96-7 N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide 
• 189291-12-1 (E)-3-[(2R,3S)-3-Methyl-1-(2,4,6-trimethyl-benzenesulfonyl)-aziridin-2-yl]-acrylic acid methyl ester 
• 189291-13-2 (Z)-3-[(2R,3S)-3-Methyl-1-(2,4,6-trimethyl-benzenesulfonyl)-aziridin-2-yl]-acrylic acid methyl ester 
• 189291-09-6 methyl (2S,3S)-3-methyl-N-[(2,4,6-trimethylphenyl)sulfonyl]-2-aziridinecarboxylate 

Relevant academic research and scientific papers

L-Threonine-derived novel bifunctional phosphine-sulfonamide catalyst-promoted enantioselective aza-morita-Baylis-Hillman reaction

A series of novel bifunctional phosphine-sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita-Baylis-Hillman (MBH) reactions. l-Threonine-derived phosphine

Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an α,β-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsvdfonyl) 2-Enoates over the Other Three Stereoisomers

Palladium(0)-catalyzed reactions of five sets of four stereoisomeric 4,5-epimino-N-(methanesulfonyl) or -N-(arylsulfonyl) 2-enoates reveal that 4,5-cis-(2E)-isomers are thermodynamically more stable than other isomers, in accord with calculations. A highly stereoselective synthesis of (E)-alkene dipeptide isosteres having the desired stereochemistries from unwanted stereoisomeric 4,5-epimino-N-(arylsulfonyl) 2-enoates is also presented.