189292-54-4Relevant academic research and scientific papers
Sulfonopeptide inhibitors of leukocyte adhesion
Carson, Kenneth G.,Schwender, Charles F.,Shroff, Hitesh N.,Cochran, Nancy A.,Gallant, Debra L.,Briskin, Michael J.
, p. 711 - 714 (1997)
The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin α4β7, with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-ΨD-V-NH2, was shown to inhibit leukocyte adhesion.
