Sulfonopeptide inhibitors of leukocyte adhesion

Article abstract of DOI:10.1016/S0960-894X(97)00090-5

The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin α₄β₇, with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-ΨD-V-NH₂, was shown to inhibit leukocyte adhesion.