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189298-47-3

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189298-47-3 Usage

Description

(S)-Meclizine, an antihistamine and anticholinergic drug, is utilized for the treatment of motion sickness and vertigo. It operates by blocking the action of histamine and acetylcholine in the brain, subsequently diminishing the symptoms of dizziness, nausea, and vomiting related to these conditions. The drug is accessible in various forms, including tablets, chewable tablets, and oral suspension, and is generally safe and well-tolerated when taken as directed. However, it may cause side effects such as drowsiness, dry mouth, and blurred vision, and should be used with caution in individuals with specific medical conditions like glaucoma, asthma, and urinary retention.

Uses

Used in Pharmaceutical Industry:
(S)-Meclizine is used as an antihistamine and anticholinergic agent for the treatment of motion sickness and vertigo. It alleviates the symptoms of dizziness, nausea, and vomiting associated with these conditions by blocking the action of histamine and acetylcholine in the brain.

Check Digit Verification of cas no

The CAS Registry Mumber 189298-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,2,9 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 189298-47:
(8*1)+(7*8)+(6*9)+(5*2)+(4*9)+(3*8)+(2*4)+(1*7)=203
203 % 10 = 3
So 189298-47-3 is a valid CAS Registry Number.

189298-47-3Downstream Products

189298-47-3Relevant articles and documents

Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

Bailey, J. Daniel,Iyer, Karthik S.,Leahy, David K.,Li, Xiaohan,Lipshutz, Bruce H.,Thakore, Ruchita R.

, p. 7205 - 7208 (2021/09/22)

Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

Fan, Qing-Hua,Liu, Xintong,Luo, Zhenli,Pan, Yixiao,Xu, Lijin,Yang, Ji,Yao, Zhen,Zhang, Xin

supporting information, p. 5205 - 5211 (2021/07/29)

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

DEUTERATED MECLIZINE

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Paragraph 130; 131; 132; 133, (2017/02/24)

This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating d

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