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Dexamethasone 21-iodoacetate is a chemical compound derived from dexamethasone, a potent synthetic glucocorticoid used in medical treatments for various inflammatory and immune-related conditions. The addition of the iodoacetate group at the 21st carbon position of the dexamethasone molecule enhances its ability to inhibit the activity of phospholipase A2, an enzyme involved in the production of inflammatory mediators. This modification makes dexamethasone 21-iodoacetate a more effective anti-inflammatory agent, with potential applications in research and therapeutics.

1893-66-9

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1893-66-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1893-66-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,9 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1893-66:
(6*1)+(5*8)+(4*9)+(3*3)+(2*6)+(1*6)=109
109 % 10 = 9
So 1893-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C24H30FIO6/c1-13-8-17-16-5-4-14-9-15(27)6-7-21(14,2)23(16,25)18(28)10-22(17,3)24(13,31)19(29)12-32-20(30)11-26/h6-7,9,13,16-18,28,31H,4-5,8,10-12H2,1-3H3/t13-,16+,17+,18+,21+,22+,23?,24+/m1/s1

1893-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-[(8S,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2-iodoacetate

1.2 Other means of identification

Product number -
Other names Dexamethasone 21-iodoacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1893-66-9 SDS

1893-66-9Downstream Products

1893-66-9Relevant academic research and scientific papers

Affinity-Labelling Corticoids I. Synthesis of 21-Chloroprogesterone, Deoxycorticosterone 21-(1-Imidazole) Carboxylate, 21-Deoxy-21-Chloro Dexamethasone, and Dexamethasone 21-Mesylate, 21-Bromoacetate, and 21-Iodoacetate

Dunkerton, Lois V.,Markland, Francis S.,Li, Ming P.

, p. 1 - 6 (2007/10/02)

The efficient and unambiguous preparation of several C-21 substituted affinity-labelling corticoids are described.Included is an improved procedure for the preparation of 21-chloroprogesterone and the first reported synthesis of deoxycorticosterone 21-(1-imidazole) carboxylate.Dexamethasone derivatives prepared include seperate and unambiguous synthesis of 21-deoxy-21-chlorodexamethasone and dexamethasone 21-mesylate, as well as the first reported synthesis of dexamethasone 21-bromoacetate and dexamethasone 21-iodoacetate.

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