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5-(Difluoromethyl)thiophene-2-carboxylic acid is a chemical compound characterized by a thiophene ring with a carboxylic acid group at the 2nd position and a difluoromethyl group at the 5th position. 5-(difluoromethyl)thiophene-2-carboxylic acid is recognized for its potential as a building block in the synthesis of pharmaceuticals and agrochemicals, with the difluoromethyl group contributing to enhanced biological activity and metabolic stability of the synthesized molecules. The thiophene core itself is valued for its wide-ranging pharmacological properties, such as anti-inflammatory, anticancer, and antimicrobial effects, making 5-(difluoromethyl)thiophene-2-carboxylic acid a significant intermediate in both the pharmaceutical and agrochemical sectors.

189330-23-2

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189330-23-2 Usage

Uses

Used in Pharmaceutical Industry:
5-(Difluoromethyl)thiophene-2-carboxylic acid serves as a key intermediate in the development of pharmaceutical compounds due to its ability to improve the biological activity and metabolic stability of the final products. The incorporation of the difluoromethyl group can lead to molecules with enhanced potency and selectivity, which is crucial for drug discovery and optimization processes.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(Difluoromethyl)thiophene-2-carboxylic acid is utilized as a building block for the synthesis of various agrochemicals. Its presence can enhance the effectiveness of these compounds, potentially leading to improved crop protection and management solutions.
Used in Drug Discovery:
5-(Difluoromethyl)thiophene-2-carboxylic acid is employed as a valuable tool in drug discovery, where its unique structural features can be leveraged to design molecules with specific therapeutic targets, particularly given the thiophene core's established pharmacological properties.
Used in Medicinal Chemistry:
As a component in medicinal chemistry, 5-(Difluoromethyl)thiophene-2-carboxylic acid is used for the synthesis of compounds with diverse biological activities. Its structural attributes allow for the creation of molecules that can address various medical needs, including those with anti-inflammatory, anticancer, and antimicrobial capabilities.

Check Digit Verification of cas no

The CAS Registry Mumber 189330-23-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,3,3 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 189330-23:
(8*1)+(7*8)+(6*9)+(5*3)+(4*3)+(3*0)+(2*2)+(1*3)=152
152 % 10 = 2
So 189330-23-2 is a valid CAS Registry Number.

189330-23-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(Difluoromethyl)-2-thiophenecarboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189330-23-2 SDS

189330-23-2Downstream Products

189330-23-2Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AS ITK INHIBITORS

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Page/Page column 171, (2014/03/25)

The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular ITK, pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by such kinases.

Phosphorylamides, their preparation and use

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, (2008/06/13)

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.

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