189334-19-8Relevant academic research and scientific papers
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes
Smyth,Rose,Mehrotra,Heath,Ruhter,Schotten,Seroogy,Volkots,Pandey,Scarborough
, p. 1289 - 1292 (2001)
The synthesis and biological activity of novel glycoprotein IIb-IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.
Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
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, (2008/06/13)
This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.
