189334-21-2

Upstream product

• 189334-19-8 3-tert-butoxycarbonyl-9-(4-cyanobenzoyl)-3,9-diaza-spiro[5.5]undecane 
• 173405-78-2 tert-butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 108-30-5 succinic acid anhydride 
• 352445-66-0 4-(3,9-diaza-spiro[5.5]undecane-3-carbonyl)-benzonitrile 

Relevant academic research and scientific papers

Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation

This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes

The synthesis and biological activity of novel glycoprotein IIb-IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.