18934-57-1

Basic information

• Product Name: AC-PHE-NHNH2
• Synonyms: AC-PHE-NHNH2;ACETYL-L-PHENYLALANINE HYDRAZINE
• CAS NO: 18934-57-1
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.26
• Mol File: 18934-57-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 180-180.5 °C
• Boiling Point: 552.2°Cat760mmHg
• Flash Point: 287.8°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 3.07E-12mmHg at 25°C
• Refractive Index: 1.557
• PKA: 12.34±0.50(Predicted)
• CAS DataBase Reference: AC-PHE-NHNH2(CAS DataBase Reference)
• NIST Chemistry Reference: AC-PHE-NHNH2(18934-57-1)
• EPA Substance Registry System: AC-PHE-NHNH2(18934-57-1)

Safety Data

• Hazardous Substances Data: 18934-57-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15N3O2/c1-8(15)13-10(11(16)14-12)7-9-5-3-2-4-6-9/h2-6,10H,7,12H2,1H3,(H,13,15)(H,14,16)

Upstream product

• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 3618-96-0 (S)-N-acetylphenylalanine 
• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 60-34-4 methylhydrazine 
• 13649-97-3 (S)-4-benzyl-2-methyl-4H-oxazol-5-one 
• 2361-96-8 ethyl N-acetyl-(L)-phenylalaninate 

Downstream Products

• 142182-05-6 1-(N-acetyl-L-phenylalanyl)-2-iodoacetyl hydrazine 
• 1332650-72-2 tert-butyl (S)-1-(4-((ethoxycarbonyl)methyl)-5-((S)-1-acetamido-2-phenylethyl)-4H-1,2,4-triazol-3-yl)pentylcarbamate 
• 10030-31-6 (S)-2-((S)-2-acetamido-3-phenylpropanamido)-3-phenylpropanoic acid 
• 78918-00-0 N'-acetylphenylalanyl-17β-hydroxy-17α-methylandrostano<3,2-c>pyrazole 
• 78917-99-4 3-N'-acetylphenylalanylhydrazone of 2-hydroxymethylene-17β-hydroxy-17α-methylandrostane 
• 18934-58-2 N-Acetyl-L-phenylalanin-azid 

Relevant articles and documents

Mechanochemical Encapsulation of Fullerenes in Peptidic Containers Prepared by Dynamic Chiral Self-Sorting and Self-Assembly

Molecular capsules composed of amino acid or peptide derivatives connected to resorcin[4]arene scaffolds through acylhydrazone linkers have been synthesized using dynamic covalent chemistry (DCC) and hydrogen-bond-based self-assembly. The dynamic character of the linkers and the preference of the peptides towards self-assembly into β-barrel-type motifs lead to the spontaneous amplification of formation of homochiral capsules from mixtures of different substrates. The capsules have cavities of around 800 ?3 and exhibit good kinetic stability. Although they retain their dynamic character, which allows processes such as chiral self-sorting and chiral self-assembly to operate with high fidelity, guest complexation is hindered in solution. However, the quantitative complexation of even very large guests, such as fullerene C60 or C70, is possible through the utilization of reversible covalent bonds or the application of mechanochemical methods. The NMR spectra show the influence of the chiral environment on the symmetry of the fullerene molecules, which results in the differentiation of diastereotopic carbon atoms for C70, and the X-ray structures provide unique information on the modes of peptide-fullerene interactions.

Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles

We report on the synthesis of 1,2,4-triazoles substituted with 2 or 3 amino acid side chains, using silver benzoate as a key reagent for the cyclization step. A complete study of the optical purity retention during the synthetic process leading to these c

Azapeptides as inhibitors and active site titrants for cysteine proteinases

Ester and amide derivatives of α-azaglycine (carbazic acid, H2NHCOOH), α-azaalanine, and α-azaphenylalanine (i.e., AC-L-Phe-NHN(R)CO-X, where X = H, CH3, or CH2Ph, respectively) were synthesized and evaluated as inhibitors