189347-40-8

Basic information

• Product Name: 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE
• Synonyms: 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE;AKOS MSC-0354;AKOS B007367;ART-CHEM-BB B007367
• CAS NO: 189347-40-8
• Molecular Formula: C₁₁H₁₀F₂O₃
• Molecular Weight: 228.19
• Mol File: 189347-40-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE(189347-40-8)
• EPA Substance Registry System: 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE(189347-40-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 189347-40-8(Hazardous Substances Data)

Usage

General Description

4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE is a chemical compound that is made up of atoms of carbon, hydrogen, oxygen, and fluorine. It is a yellow to light orange solid with a molecular formula of C11H11F2O3. 4,4-DIFLUORO-1-(4-METHOXY-PHENYL)-BUTANE-1,3-DIONE is used in the synthesis of pharmaceuticals and other organic chemicals. It has been studied for its potential biological and pharmaceutical applications, and its chemical structure makes it an important building block in the development of new molecules with potential medicinal properties. Due to its potential uses, it is important to handle this chemical with care and follow proper safety protocols when working with it.

Upstream product

• 454-31-9 ethyl difluoroacetate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1418197-36-0 (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol 
• 1418197-35-9 2,2-difluoro-1-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)isoxazol-5-yl]ethanol 
• 1418197-34-8 (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(phenyl)methanol 
• 1418197-33-7 2,2-difluoro-2-[3-(4-methoxyphenyl)isoxazol-5-yl]-1-phenylethanol 
• 1260813-24-8 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole 
• 929606-79-1 C₁₇H₁₃BrF₂N₂O 
• 929606-94-0 C₁₇H₁₃BrF₂N₂O 
• 151507-09-4 3-(Difluoromethyl)-5-(4-methoxyphenyl)-1-[4(methylthio)phenyl]pyrazole 

Relevant articles and documents

PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES

The present invention relates to novel pyrazolo- and imidazo-pyrimidine derivatives of formula (I) wherein A, D, E, L, M, Q, R1, R2 and R3 are as defined in the description and claims and to processes for their preparation, pharmaceutical compositions containing said derivatives and their use in the prevention and treatment of diseases.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)- 3(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide (sc-58635, celecoxib)

A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this series, and a number of potent and selective inhibitors of COX-2 were identified. Since an early structural lead (1f, SC- 236) exhibited an unacceptably long plasma half-life, a number of pyrazole analogs containing potential metabolic sites were evaluated further in vivo in an effort to identify compounds with acceptable pharmacokinetic profiles. This work led to the identification of 1i (4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-y1]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis.