1418197-33-7Relevant articles and documents
Regioselective nucleophilic addition of 3-aryl-5-difluoromethyl-isoxazoles to aldehydes
Yang, Xueyan,Fang, Xiang,Zhang, Dong,Yu, Yanlin,Zhang, Zhengdong,Wu, Fanhong
, p. 1 - 7 (2013/02/23)
A series of 5-difluoromethyl-isoxazoles 2 were prepared, and their regioselective nucleophilic addition to aldehydes was investigated. It was found that the nucleophilic difluoromethylation of aldehydes with 5-difluoromethyl-isoxazoles could be efficiently and uniquely achieved in the presence of LDA as a base that provides a large steric hindrance. In contrast, 3,4,5-trisubstituted 5-difluoromethyl isoxazoles were alternatively afforded as the sole product in moderate yields when n-BuLi was used as the base.