189393-17-7

Basic information

• Product Name: 8-BROMO-2-CHLORO-11-ETHYL-5-METHYL-5H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6(11H)-ONE
• Synonyms: 8-BROMO-2-CHLORO-11-ETHYL-5-METHYL-5H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6(11H)-ONE
• CAS NO: 189393-17-7
• Molecular Formula: C₁₄H₁₂BrClN₄O
• Molecular Weight: 367.63
• Mol File: 189393-17-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BROMO-2-CHLORO-11-ETHYL-5-METHYL-5H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6(11H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-2-CHLORO-11-ETHYL-5-METHYL-5H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6(11H)-ONE(189393-17-7)
• EPA Substance Registry System: 8-BROMO-2-CHLORO-11-ETHYL-5-METHYL-5H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6(11H)-ONE(189393-17-7)

Safety Data

• Hazardous Substances Data: 189393-17-7(Hazardous Substances Data)

Upstream product

• 189393-15-5 8-bromo-2-chloro-5,11-dihydro-11-ethyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 189393-13-3 N-(2,6-dichloro-3-pyridinyl)-5-bromo-2-ethylamino-3-pyridinecarboxamide 
• 189393-12-2 N-(2,6-dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide 
• 189393-11-1 N-(2,6-dichloro-3-pyridinyl)-2-chloro-3-pyridinecarboxamide 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 62476-56-6 3-amino-2,6-dichloropyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 189391-33-1 8-[2-(4-aminophenyl)ethyl]-2-chloro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 189392-14-1 7-Chloro-5-ethyl-10-methyl-2-(3-nitro-phenoxymethyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 
• 189392-40-3 3-(7-Chloro-5-ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-2-ylmethoxy)-benzoic acid methyl ester 
• 189392-42-5 2-chloro-5,11-dihydro-11-ethyl-8-(3-(carboxy)phenyloxy)methyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 

Relevant articles and documents

Non-nucleoside reverse transcriptase inhibitors

Provided are compounds of the general formula I: wherein R2 is selected from the group consisting of H, F, Cl, (C1-4) alkyl, (C3-4) cycloalkyl and CF3; R4 is H or Me; R5 is H, Me or Et, wit

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8- Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones

Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a result of a second generation program around the tricyclic core system of nevirapine, 2-chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2- (pyridin-4-yl)ethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (II)1a and 2-chloro-5,11dihydro-11-ethyl-5-methyl-8-phenylethyl-6H-dipyrido[3-2- b:2',3'-e][1,4]diazepin-6-one (III)1a were identified as broad spectrum HIV-1 RT inhibitors. A detailed examination of replacing either of the methylenes of the 8-ethyl linker of II or III is presented. It was found that 8-aryloxymethyl and 8-arylthiomethyl are the preferred pattern of substitution for potency against RT. The most potent compounds were further evaluated against a panel of clinically significant mutant RT enzymes (K103N, V106A, G190A, P236L) and in cytotoxicity and in vitro metabolism assays. The most potent compound was 2-chloro-8-phenylthiomethyl analogue 37 which displayed sub-100 nM activity against all HIV-1 RT enzymes tested.