189439-48-3Relevant academic research and scientific papers
Rapid access to β-trifluoromethyl-substituted ketones: Harnessing inductive effects in wacker-type oxidations of internal alkenes
Lerch, Michael M.,Morandi, Bill,Wickens, Zachary K.,Grubbs, Robert H.
supporting information, p. 8654 - 8658 (2014/08/18)
We present a practical trifluoromethyl-directed Wacker-type oxidation of internal alkenes that enables rapid access to β-trifluoromethyl-substituted ketones. Allylic trifluoromethyl-substituted alkenes bearing a wide range of functional groups can be oxidized in high yield and regioselectivity. The distance dependence of the regioselectivity was established by systematic variation of the number of methylene units between the double bond and the trifluoromethyl group. The regioselectivity enforced by traditional directing groups could even be reversed by introduction of a competing trifluoromethyl group. Besides being a new powerful synthetic method to prepare fluorinated molecules, this work directly probes the role of inductive effects on nucleopalladation events.
Therapeutic Agents 684
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Page/Page column 13, (2008/12/04)
Certain 4,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one and 4,5-dihydropyrrolo[3,2-c]pyridin-4-one compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, methods for the
