18951-35-4Relevant articles and documents
Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle
Van Der Peet,Gunawan, Christian,Torigoe, Shota,Yamasaki, Sho,Williams, Spencer J.
, p. 5100 - 5103 (2015)
An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.
Enantioselective Hydrogenation of β-Keto Esters using Chiral Diphosphine-Ruthenium Complexes: Optimization for Academic and Industrial Purposes and Synthetic Applications
Ratovelomanana-Vidal,Girard,Touati,Tranchier,Ben Hassine,Genet
, p. 261 - 274 (2007/10/03)
Enantioselective hydrogenation using chiral complexes between atropisomeric diphosphines and ruthenium is a powerful tool for producing chiral compounds. Using a simple and straightforward in situ catalyst preparation, the conditions were optimized using molecular hydrogen for both academic and industrial purposes. This led to the best conditions and the lowest catalytic ratio required for the pressure used. Hydrogenation of various β-keto esters was efficiently performed at atmospheric and higher pressures, leading to the use of very low catalyst-substrate ratios up to 1/20,000. Asymmetric hydrogenations were used in key-steps towards the total synthesis of corynomycolic acid, Duloxetine and Fluoxetine.
Trehalose derivatives
-
, (2008/06/13)
A trehalose derivative of the formula: STR1 wherein one, two, three or four of R1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from the group consisting o