18952-15-3Relevant academic research and scientific papers
Enzyme-promoted kinetic resolution of racemic, P-chiral phosphonyl and phosphorylacetates
Kielbasinski, Piotr,Goralczyk, Piotr,Mikolajczyk, Marian,Wieczorek, Michal W.,Majzner, Wieslaw R.
, p. 2641 - 2650 (2007/10/03)
A series of racemic methyl phosphonyl- and phosphorylacetates were hydrolyzed in the presence of porcine liver esterase (PLE) under kinetic resolution conditions to give the corresponding P-chiral phosphonyl- and phosphorylacetic acids and recovered esters in moderate to high enantiomeric purity (up to 95% ee). The Jones PLE active site model was applied to explain the enantioselectivity of this reaction.
Enzymatic synthesis of chiral, non-racemic phosphoryl compounds
Kie?basin?ski, Piotr,Miko?ajczyk, Marian
, p. 497 - 500 (2007/10/03)
A series of phosphinyl-, phosphonyl- and phosphorylacetates was hydrolyzed in the presence of Pig Liver Esterase (PLE) to give the corresponding P-chiral phosphoroacetic acids and unreacted esters in a high enantiomeric purity (up to 100% ee).
