189623-63-0

Upstream product

• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 6531-08-4 3,6-dichloropyridazine-5-carboxylic acid chloride 
• 75-03-6 ethyl iodide 
• 189623-61-8 3,6-dichloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamide 

Downstream Products

• 189623-69-6 6-Chloro-3-propylamino-pyridazine-4-carboxylic acid (2-chloro-5-nitro-phenyl)-ethyl-amide 
• 189623-66-3 6-Chloro-3-ethylamino-pyridazine-4-carboxylic acid (2-chloro-5-nitro-phenyl)-ethyl-amide 
• 189623-71-0 6-Chloro-3-cyclopropylamino-pyridazine-4-carboxylic acid (2-chloro-5-nitro-phenyl)-ethyl-amide 

Relevant academic research and scientific papers

Synthesis of pyridazino[3,4-b][1,5]benzodiazepin-5-ones and their biological evaluation as non-nucleoside HIV reverse transcriptase inhibitors

Starting from 3,6-dichloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamine (7) a series of 6,11-dialkylated pyridazino-[3,4-b][1,5]benzodiazepin-5-ones with a 3-chloro-8-nitro, 8-amino, 8-acetylamino, or 8-chloro substitution pattern was prepared via N-alkyl-3-alkylamino-6-chloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4- carboxamides. The new compounds were screened as non-nucleoside reverse transcriptase inhibitors. The influence of the substitution pattern in compounds 10-13 on inhibitory potency is discussed.