189626-00-4

Upstream product

• 30018-16-7 (1-ethoxycarbonylethyl)triphenylphosphonium bromide 
• 35675-44-6 4-methylphenylacetyl chloride 

Downstream Products

• 1206896-57-2 ethyl 3-fluoro-2-methyl-4-(4'-methylphenyl)-4-oxo-2(E)-butenoate 
• 1206896-63-0 4-fluoro-3-methyl-5-(4'-methylphenyl)-2(5H)-furanone 
• 1227751-52-1 ethyl 2-methyl-4-(p-tolyl)-4-(2,4,6-trimethoxyphenyl)but-2(E)-enoate 
• 1380396-90-6 ethyl (2E)-5-acetyl-2-methyl-4-(4-methylphenyl)-6-oxohept-2-enoate 
• 1280135-89-8 ethyl 2-methyl-4-(4-methylphenyl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate 
• 1280135-98-9 ethyl 2-methyl-4-(4-methylphenyl)-4-(1-tosyl-1H-indol-3-yl)but-2(E)-enoate 

Relevant academic research and scientific papers

Study on the selectivity in the electrophilic monofluorination of 2,3-allenoates with Selectfluor: An efficient synthesis of 4-fluoro-2(5H)-furanones and 3-fluoro-4-oxo-2(E)-alkenoates

Different from the reaction of 2,3-allenoic acids with Selectfluor, 4-fluoro-2(5H)-furanones and (E)-3-fluoro-4-oxo-2-alkenoates were highly selectively generated from 2,4-disubstituted 2,3-allenoates with Selectfluor under different conditions in moderate yields. The reaction of 2, 4, 4-trisubstituted 2,3-allenoates afforded the corresponding 4-fluoro-2(5H)-furanones highly selectively with up to 95% yield under different conditions. The scope of the substrates has been carefully explored. Due to the more readily availability of 2,3-allenoates as compared to 2,3-allenoic acids, new 4-fluoro-2(5H)furanones were prepared. Based on the isolation and characterization of the minor fluorohydroxylation product E-5m, a mechanism has been proposed. The Royal Society of Chemistry 2010.