30018-16-7

Basic information

• Product Name: [1-(Ethoxycarbonyl)ethyl]triphenylphosphonium bromide
• Synonyms: CARBOETHOXYETHYL TRIPHENYLPHOSPHONIUM BROMIDE;(1-ETHOXYCARBONYLETHYL)TRIPHENYLPHOSPHONIUM BROMIDE;1-CARBETHOXYETHYL TRIPHENYLPHOSPHONIUM BROMIDE;(2-ethoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide;carbethoxy Ethyl Triphenyl Phosphonium Bromide;(1-ETHOXYCARBONYLETHYL)TRIPHENYLPHOSPHONIUM BROMIDE 96%;1-Carbethoxyethyl triphenylphosphonium bromide 98%;(1-carboethoxyethyl)triphenylphosphonium bromide
• CAS NO: 30018-16-7
• Molecular Formula: Br*C₂₃H₂₄O₂P
• Molecular Weight: 443.31
• EINECS: 250-002-2
• Product Categories: Isoquinolines ,Quinolines ,Quinazolines ,Quinaldines
• Mol File: 30018-16-7.mol
• Article Data: 25

Chemical Properties

• Melting Point: 152 °C
• Appearance: White to off-white powder
• Storage Temp.: Refrigerator (+4°C)
• Solubility: Chloroform, Methanol
• Water Solubility: soluble
• Sensitive: Hygroscopic
• BRN: 3822244
• CAS DataBase Reference: [1-(Ethoxycarbonyl)ethyl]triphenylphosphonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(Ethoxycarbonyl)ethyl]triphenylphosphonium bromide(30018-16-7)
• EPA Substance Registry System: [1-(Ethoxycarbonyl)ethyl]triphenylphosphonium bromide(30018-16-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-29-22
• Safety Statements: 26-36-8-37/39
• Hazardous Substances Data: 30018-16-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Different sources of media describe the Uses of 30018-16-7 differently. You can refer to the following data:
1. suzuki reaction
2. 1-Ethoxycarbonylethyl)triphenylphosphonium bromide is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is widely used as an organophosphine catalyst.

InChI:InChI=1/C23H24O2P.BrH/c1-3-25-23(24)19(2)26(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22;/h4-19H,3H2,1-2H3;1H/q+1;/p-1

Upstream product

• 74-83-9 methyl bromide 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 603-35-0 triphenylphosphine 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 5717-41-9 ethyl 2-methylbuta-2,3-dienoate 
• 182617-13-6 (E)-3-{(2R,3R)-3-[(2S,3R,4S,6S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-6-(4-methoxy-benzyloxy)-3-methyl-octyl]-2-methyl-oxiranyl}-2-methyl-acrylic acid ethyl ester 
• 92576-43-7 ethyl 3-(4-chlorophenyl)-2-methyl-2-propenoate 
• 1200041-07-1 ethyl (S)-5-(4-(benzyloxy)phenyl)-4-(tert-butoxycarbonylamino)-2-en-2-methylpentanoate 
• 355015-07-5 ethyl 2-methylhepta-2,3-dienoate 
• 55514-49-3 ethyl (E)-γ-bromo-α-methylbut-2-enoate 
• 1200041-26-4 ethyl (2R,4R)-5-(4-(hydroxy)phenyl)-4-(tert-butoxycarbonylamino)-2-methylpentanoate 
• 1616135-57-9 ethyl 3-(dimethyl(phenyl)silyl)-2-methylbut-3-enoate 
• 1092696-40-6 ethyl 2,5,5-trimethylhexa-2,3-dienoate 

Relevant articles and documents

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Close the ring to break the cycle: Tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-: A] quinolin-5-ones with potent anti-protozoal activity

Expanding the chemical space of quinolones led to a tandem quinolone-alkyne-cyclisation reaction allowing chemoselective control of the synthesis of tricyclic pyrrolo[1,2-a]quinolin-5-ones. Importantly, we discovered anti-protozoal activity against Plasmodium and Toxoplasma with specific potency of one of the compounds against the liver stage of the malaria parasite in the nanomolar range.