189636-47-3

Upstream product

• 100-39-0 benzyl bromide 
• 1026052-77-6 C₂₂H₂₇NO₃ 
• 195207-51-3 4-(S)-(N,N-dibenzylamino)-2,2-dimethyl-3-oxopentanenitrile 

Downstream Products

• 189636-72-4 (S)-Methyl-phosphonic acid (S)-2-cyano-1-((S)-1-dibenzylamino-ethyl)-2,2-dimethyl-ethyl ester phenyl ester 
• 208765-02-0 (3S,4S)-1-Amino-4-dibenzylamino-2,2-dimethyl-pentan-3-ol 
• 208765-06-4 Methyl-phosphonic acid (S)-1-((S)-1-dibenzylamino-ethyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2,2-dimethyl-propyl ester 2-trimethylsilanyl-ethyl ester 
• 208765-04-2 2-((3S,4S)-4-Dibenzylamino-3-hydroxy-2,2-dimethyl-pentyl)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Stereoselective synthesis of the four stereoisomers of 4-(N,N- dibenzylamino)-2,2-dimethyl-3-hydroxypentanenitrile

The title compounds 1(a,b) and 1(c,d) were synthesized by (i) non- chelation controlled sodium borohydride reduction of their corresponding α- N,N-dibenzylaminoketones and (ii) the Aldol-type condensation of optically pure N,N-dibenzylaminoaldehydes with the lithium derivative of isobutyronitrile, respectively. Attempted inversion of configurations of these secondary alcohols using the Moriarty method yielded 4 -chloro-3 -N,N- dibenzylaminonitrile via an aziridinium ion intermediate instead of the expected inverted alcohols.