185254-52-8

Upstream product

• 135710-38-2 3,5-bis(2-propen-1-yloxy)benzoic acid methyl ester 
• 189684-08-0 allyl 3,5-bis(allyloxy)benzoate 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 106-95-6 allyl bromide 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 

Downstream Products

• 185254-55-1 1,4-bis[3,5-bis(allyloxy)benzoyloxy]benzene 
• 1000773-37-4 3,5-bis(allyloxy)benzoic acid chloride 
• 932380-52-4 3,5-bis(allyloxy)-N-(benzyloxy)benzamide 
• 1404616-62-1 N-(3,5-(diallyloxy)benzoyl)-8-aminoquinoline 
• 73338-85-9 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran 
• 159507-53-6 1,4-bis[3,5-dihydroxybenzoyloxy]benzene 
• 873332-52-6 5'-(3,5-bis(allyloxy)benzoyl)-2',3'-isopropylidene guanosine 

Relevant academic research and scientific papers

Mixing End Groups in Thiol-Ene/Yne Reactions as a Simple Approach toward Multienzyme-Responsive Polymeric Amphiphiles

Taking advantage of the high fidelity of thiol-ene and thiol-yne chemistries, we used mixtures of thiols to prepare degradable PEG-dendron amphiphiles functionalized with two different types of enzymatically cleavable end groups. By tuning the feed ratios of the two thiols, we achieved mixtures of hybrids with statistically different ratios of end groups. Studies of the disassembly of statistically mixed hybrids showed that these amphiphiles have higher degrees of response when incubated with each of the activating enzymes, whereas a greater degree of selectivity was observed for a control mixture of two distinct amphiphiles, which required the presence of both types of enzyme to undergo complete disassembly. The potential to introduce different end groups by using a mixture of thiols in an efficient single thiol-ene or thiol-yne step opens the way for simple modification of various ene- or yne-containing polymers and tailoring of their structural and functional properties.

Green synthesis of (R)-terbutaline for recyclable catalytic asymmetric transfer hydrogenation in ionic liquids

We synthesize optically active (R)-terbutaline 2, which is an anti-asthmatic drug, through recyclable catalytic asymmetric transfer hydrogenation (RCATH). Various chloroketones 4 were prepared and RCATH was performed on them. The products exhibit moderate

Synthetic method for moracin F using Sonogashira coupling reaction

The present invention relates to a method for synthesizing a natural compound, moracin F having biological activity. The synthesis method of the present invention can efficiently synthesize the moracin F having biological activity by using Sonogashira cou

Synthetic method for moracin F using intramolecular Wittig reaction

The present invention provides a method for synthesizing a natural compound moracin F having biological activity. When using the method of the present invention, moracin F having a biological activity can be effectively synthesized by using an intramolecu

Synthetic method for moracin F using Suzuki coupling reaction

An objective of the present invention is to provide a method for synthesizing a natural compound moracin F having biological activity. Inventors of the present invention can efficiently synthesize moracin F having biological activity by using Suzuki coupl

Diversity oriented synthesis of natural 2-arylbenzofuran, moracin F

Diversity oriented synthesis of natural 2-arylbenzofuran, moracin F (1) has been carried out from the commercially available starting materials using Sonogashira coupling, Suzuki coupling, neutral Al2O3 mediated cyclization, and intr

The effect of photoisomerization on the enzymatic hydrolysis of polymeric micelles bearing photo-responsive azobenzene groups at their cores

The design of stable polymeric micelles that can respond to specific stimuli is crucial for the development of smart micellar nanocarriers that can release their active cargo selectively at the target site, thus diminishing the therapeutic limitations due to non-selective damage to healthy tissues. Here we report the design and synthesis of photo- and enzyme-responsive amphiphilic PEG-dendron hybrids bearing one, two or four enzymatically cleavable azobenzene end-groups. These dual-responsive hybrids can respond to light through the reversible isomerization of the azobenzene end-groups from the non-polar trans isomer to the highly polar cis isomer and vice versa, upon UV and visible irradiation, respectively. The high structural precision of these hybrids, which emerges from the dendritic architecture, enabled a detailed study of the photoisomerization of the azobenzene end-groups with high molecular resolution. Remarkably, although the transition from trans-to-cis led to a significant increase in the polarity of the micellar cores, the micelles remained stable. Our kinetic studies show that although the trans isomer is a better substrate for the activating enzyme, the UV induced formation of the cis azobenzene end-groups led to significant acceleration of the enzymatic hydrolysis of the end-groups. These results provide strong indication that the enzyme cannot reach the core of the micelles and instead the end-groups have to leave the hydrophobic core in order to be exposed on the micelle's surface or even leave the micelle in order to allow their cleavage by the activating enzymes.

Rh(iii)-Catalyzed intramolecular redox-neutral cyclization of alkenes via C-H activation

Biologically interesting fused oligocyclic lactams have been prepared via an intramolecular redox-neutral cyclization process. By the proper choice of the substrates with a wide variety of tethered olefins, the less favored C-H bond can be activated and f

Inhibitors of the FEZ-1 metallo-β-lactamase

Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.

Induction of liquid crystallinity by host-guest interactions

A molecular clip is described which binds aromatic guests by an induced fit mechanism. It contains twelve long aliphatic chains and can evoke liquid-crystalline properties in a variety of molecules, including polymers and porphyrins, by a process of molecular recognition.