189684-50-2 Usage
Uses
Used in Research Applications:
Ac-DEVD-pNA is used as a substrate for studying caspase activity and apoptosis in various research applications. It allows for the colorimetric monitoring of caspase cleavage, providing a convenient and reliable method for assessing caspase activity in cell cultures, tissue samples, and other biological systems.
Used in Drug Discovery and Development:
Ac-DEVD-pNA is also used in drug discovery and development for identifying and evaluating compounds that modulate caspase activity. By monitoring the cleavage of Ac-DEVD-pNA, researchers can screen for potential inhibitors or activators of caspases, which may have therapeutic applications in treating diseases associated with apoptosis, such as cancer and neurodegenerative disorders.
Used in Diagnostic Applications:
Ac-DEVD-pNA can be employed as a diagnostic tool for detecting and monitoring caspase activity in various clinical samples. Its colorimetric readout allows for easy and accurate measurement of caspase activity, which can be useful for diagnosing and monitoring diseases associated with abnormal apoptosis or for assessing the efficacy of treatments targeting caspases.
Check Digit Verification of cas no
The CAS Registry Mumber 189684-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,6,8 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 189684-50:
(8*1)+(7*8)+(6*9)+(5*6)+(4*8)+(3*4)+(2*5)+(1*0)=202
202 % 10 = 2
So 189684-50-2 is a valid CAS Registry Number.
189684-50-2Relevant academic research and scientific papers
Using peptidic inhibitors to systematically probe the S1′ site of caspase-3 and caspase-7
Goode, David R.,Sharma, Anil K.,Hergenrother, Paul J.
, p. 3529 - 3532 (2007/10/03)
(Chemical Equation Presented) Fifteen ketone-containing peptides were designed, synthesized, and used to probe the effect of substitution at the P1′ position on caspase-3 and -7 inhibition. Even with the large bias of Ac-Asp-Glu-Val-Asp at the P4-P1 positions, certain peptides with cyclic functionality in the P1′ position show a dramatically reduced ability to inhibit these caspases. Additionally, trends toward isozyme selectivity were also uncovered for particular P1′ substituents. The data indicate that substitution in the P1′ position can drastically affect both caspase inhibition and selectivity.
