189744-46-5 Usage
Uses
Used in Pharmaceutical Industry:
Ro 10-5824 Dihydrochloride is used as a therapeutic agent for the treatment of psychiatric and neurological disorders. Its selective action on dopamine D4 receptors makes it a promising candidate for the management of conditions such as schizophrenia, bipolar disorder, and major depressive disorder.
Used in Research Applications:
In addition to its clinical applications, Ro 10-5824 Dihydrochloride is also used as a research tool to study the role of dopamine D4 receptors in cognitive processes, memory, learning, and motor control. Its selective binding to these receptors allows researchers to investigate the underlying mechanisms of dopamine-related disorders and develop novel therapeutic strategies.
Used in Drug Development:
Ro 10-5824 Dihydrochloride serves as a lead compound in the development of new drugs targeting dopamine D4 receptors. Its unique pharmacological properties can be leveraged to design more effective and safer medications for the treatment of various psychiatric and neurological conditions.
Biological Activity
Selective dopamine D 4 receptor partial agonist (EC 50 = 205 nM) that binds with high affinity (K i = 5.2 nM). Displays 250-fold selectivity over D 3 receptors and > 1000-fold selectivity over D 2 , D 1 and D 5 receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 189744-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,7,4 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 189744-46:
(8*1)+(7*8)+(6*9)+(5*7)+(4*4)+(3*4)+(2*4)+(1*6)=195
195 % 10 = 5
So 189744-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N4.2ClH/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14;;/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20);2*1H
189744-46-5Relevant academic research and scientific papers
Pyrimidine compounds
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 and R2 each individually are lower-alkyl or amino, A is STR2 B is hydrogen in A4, A5 and A6 ; STR3 in A1 -A6 ; lower-alkoxy in A4/s
