189744-46-5

Basic information

• Product Name: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
• Synonyms: RO 10-5824;5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE;Ro 10-5824 dihydrochloride;2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine
• CAS NO: 189744-46-5
• Molecular Formula: C₁₇H₂₀N₄
• Molecular Weight: 353.28938
• Mol File: 189744-46-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 506.2°C at 760 mmHg
• Flash Point: 260°C
• Appearance: /
• Vapor Pressure: 1.28E-10mmHg at 25°C
• Storage Temp.: Desiccate at RT
• CAS DataBase Reference: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE(189744-46-5)
• EPA Substance Registry System: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE(189744-46-5)

Safety Data

• Hazardous Substances Data: 189744-46-5(Hazardous Substances Data)

Usage

Uses

The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Ro 10-5824 Dihydrochloride is a selective dopamine D4?receptor partial agonist (2).

Biological Activity

Selective dopamine D 4 receptor partial agonist (EC 50 = 205 nM) that binds with high affinity (K i = 5.2 nM). Displays 250-fold selectivity over D 3 receptors and > 1000-fold selectivity over D 2 , D 1 and D 5 receptors.

InChI:InChI=1/C17H20N4.2ClH/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14;;/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20);2*1H

Upstream product

• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 70476-08-3 4-Amino-5-chloromethyl-2-methylpyrimidinium hydrochloride 

Relevant articles and documents

Pyrimidine compounds

Compounds of the formula STR1 wherein R1 and R2 each individually are lower-alkyl or amino, A is STR2 B is hydrogen in A4, A5 and A6 ; STR3 in A1 -A6 ; lower-alkoxy in A4/s