43064-12-6 Usage
Description
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a chemical compound that features a 4-phenyl-1,2,3,6-tetrahydropyridine fragment, which is a key structural element in benzamide derivatives. This fragment enhances the inhibitory potential of benzamide analogs against poly(ADP-ribose) polymerase-1 (PARP-1), a significant enzyme involved in various cellular processes. 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is characterized by its light brown powder form.
Uses
Used in Pharmaceutical Industry:
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is used as a pharmaceutical intermediate for the development of drugs targeting poly(ADP-ribose) polymerase-1 (PARP-1). Its presence in benzamide analogs improves their inhibitory potential against PARP-1, making it a valuable component in the creation of therapeutic agents for treating various diseases, including cancer.
Used in Research and Development:
In the field of scientific research, 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride serves as a key compound for studying the interactions between PARP-1 and benzamide derivatives. This research can lead to a better understanding of the enzyme's role in disease processes and the development of more effective treatments.
Used in Drug Synthesis:
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is utilized in the synthesis of novel drugs that aim to modulate the activity of PARP-1. Its incorporation into drug molecules can enhance their efficacy and selectivity, potentially leading to improved therapeutic outcomes for patients.
Overall, 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride plays a crucial role in the pharmaceutical and research industries, contributing to the advancement of treatments for various diseases and the deepening of our understanding of PARP-1's biological functions.
Check Digit Verification of cas no
The CAS Registry Mumber 43064-12-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,6 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 43064-12:
(7*4)+(6*3)+(5*0)+(4*6)+(3*4)+(2*1)+(1*2)=86
86 % 10 = 6
So 43064-12-6 is a valid CAS Registry Number.
43064-12-6Relevant articles and documents
POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS
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Page/Page column 42, (2018/07/29)
The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.