189756-89-6

Usage

Uses

Used in Personal Care Products:
4-BROMO-[1,2]OXATHIOLANE 2,2-DIOXIDE is used as a preservative in personal care products to maintain their freshness and prevent microbial contamination, ensuring product safety and efficacy.
Used in Cosmetics:
In the cosmetics industry, 4-BROMO-[1,2]OXATHIOLANE 2,2-DIOXIDE is used as a preservative to protect cosmetic products from microbial growth, thus extending their shelf life and maintaining their quality.
Used in Household Cleaners:
4-BROMO-[1,2]OXATHIOLANE 2,2-DIOXIDE is used as a preservative in household cleaners to prevent the growth of bacteria and fungi, ensuring the effectiveness of the cleaning products and maintaining their quality.
However, it is important to note that 4-BROMO-[1,2]OXATHIOLANE 2,2-DIOXIDE has been associated with allergic contact dermatitis in some individuals and is considered a potential skin sensitizer. Additionally, there have been concerns about its potential to release formaldehyde, a known carcinogen, when it reacts with other chemicals. As a result, there have been restrictions and bans on the use of 4-BROMO-[1,2]OXATHIOLANE 2,2-DIOXIDE in certain countries and industries to ensure consumer safety and environmental protection.

InChI:InChI=1/C3H5BrO3S/c4-3-1-7-8(5,6)2-3/h3H,1-2H2

Upstream product

• 51116-03-1 sodium 2,3-dibromopropane-1-sulfonate 
• 14418-84-9 allylsulfonyl chloride 
• 769861-83-8 2,3-dibromopropane-1-sulfonic acid 
• 2495-39-8 sodium prop-2-ene-1-sulfonate 

Downstream Products

• 21806-61-1 1-propenyl-1,3-sulfonic acid lactone 

Relevant academic research and scientific papers

1,3-Dipolar Cycloaddition Reactions of Nitrile Oxides to Prop-1-ene-1,3-sultone

The reaction of prop-1-ene-1,3-sultone 1 with a variety of nitrile oxides 3 afforded novel [3+2] cycloaddition products 4 in good yield. The cycloaddition reaction achieved excellent regioselectivity.

Synthesis and Diels-Alder reactions of α,β-unsaturated γ-sultone

An efficient synthesis of prop-1-ene 1,3-sultone 1 and its Diels-Alder reactions are reported; ring-opening reactions of the cycloadducts with nucleophiles and transformations to the sultams were also investigated.

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

1,3-Dipolar cycloaddition reactions of nitrones to prop-1-ene-1,3-sultone

The reaction of prop-1-ene-1,3-sultone (1) with a variety of nitrones 2 afforded novel [3+2] cycloaddition products 3, 4, and 5 in good yield. Excellent regio- and stereoselectivity were achieved in the cycloaddition reaction with phenylnitrones.

Synthesis and Diels-Alder reactions of prop-1-ene-1,3-sultone, and chemical transformations of the Diels-Alder adducts

A reliable and novel synthetic route for the preparation of prop-1-ene- 1,3-sultone (1) has been developed. An overall yield of 34% could be achieved for this five-step synthesis. The Diels-Alder reactions of 1 with a variety of dienes were investigated for the first time and achieved with good chemical yield and excellent endo-selectivity. The subsequent transformations of the Diels-Alder cycloadducts were also explored.

Synthesis of 1-alkene-1,3-sultones from 2,3-epoxy-alkanesulfonyl chlorides

Dehydrochlorination of αβ-epoxy sulfonyl chlorides 3 leads to 1-alkene-1,3-sultones 1 most probably via epoxy sulfenes 2.