189762-98-9

Upstream product

• 1011-17-2 2-hydroxyphenylpiperazine 
• 50-00-0 formaldehyd 
• 148547-51-7 N-methyl-N'-(2-methoxyphenyl)-piperazine 

Downstream Products

• 934474-78-9 methyl 2-(2-(4-methyIpiperazin-1-yl)phenoxy)acetate 
• 1620294-66-7 1-(2-(allyloxy)phenyl)-4-methylpiperazine 
• 1620294-68-9 tert-butyl ((5-((2-(4-methylpiperazin-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate 

Relevant academic research and scientific papers

PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF

Disclosed herein is a compound of Formula (AIII) or (III), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS

The present invention provides substituted 4,5-dihydroisoxazole derivatives of formula (I), which may be therapeutically useful, more particularly NAMPT inhibitors and in which R1 R2, Y, X, "Het" and "p" have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPT) in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted 4,5-dihydroisoxazole derivatives of formula (I) or a pharmaceutically acceptable salts or stereoisomers or N-oxide thereof.

PYRIDOPYRIMIDINONE INHIBITORS OF PIM-1 AND/OR PIM-3

Compounds of formula I, useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4 are as defined above. Pharmaceutical compositions and methods of treating diseases and conditions, such as cancer, are also disclosed.