189764-71-4Relevant academic research and scientific papers
Synthesis of microcolin analogs using trimethylsilylated lactams
Mattern, Ralph-Heiko,Gunasekera, Sarath P.,McConnell, Oliver J.
, p. 2197 - 2200 (1997)
The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity.
